Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury

Autor: Alexandra K. Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E. Simopoulos
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Investigative Surgery, Vol 31, Iss 6, Pp 491-502 (2018)
Druh dokumentu: article
ISSN: 0894-1939
1521-0553
08941939
46838147
DOI: 10.1080/08941939.2017.1360416
Popis: Purpose: We investigated the hepatoprotective effect of Silibinin (SLB) to ischemia-reperfusion (I/R) rat model, by evaluating the histological expression of the tissue markers Fas/FasL, HMGB-1 and CD45, and SLB pharmacokinetics. Methods: Seventy-three Wistar-type male rats were randomized in 11 groups: Sham control group (open-close laparotomy); four I/R control groups (laparotomy, 45 min vascular occlusion, reperfusion, euthanasia after 60, 120, 180, and 240 min); four SLB (Si) groups (laparotomy, 45 min vascular occlusion, IV administration of SLB, reperfusion, euthanasia after 60, 120, 180, and 240 min); two SLB pharmacokinetics (PK) groups (IV administration of SLB, euthanasia after 45 and 240 min). Results: Fas/FasL increased with reperfusion time in I/R control groups and decreased in the Si groups, reaching, respectively, the highest and lowest values at 240 min of reperfusion (p
Databáze: Directory of Open Access Journals
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