Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease
| Autor: | Z. Carl Lin, F. S. Hall, R. L. Bell |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, Vol 0, Iss 4-1, Pp 36-38 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2313-7053 2713-055X |
| DOI: | 10.31363/2313-7053-2019-4-1-36-38 |
| Popis: | It is established that Substance use disorders (SUDs) and Parkinson’s Disease (PD) among many other neuropsychiatric disorders are dopamine (DA)-related brain disorders with strong heritability. However, it is unclear whether DA-associated genetic risks share commonality across these disorders. This study utilizes the Genotype and Phenotype Database (dbGaP), by downloading related genome-wide association studies (GWAS) for individual genotype/phenotypes. According to our results DA pathways are significantly implicated in the genetic etiology of both SUDs and PD but much more in the former. Epistatic effects may represent a major portion of missing heritability observed in current main effect-oriented GWAS analyses. |
| Databáze: | Directory of Open Access Journals |
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