L–Thyroxine induced hyperthyroidism effect on Testicular endoplasmic reticulum stress and Perk–mediated Nrf2/HO–1 signaling axis of rats
| Autor: | Gözde Arkalı, Şeyma Özer Kaya, Songül Çeribaşı, Edanur Güler Ekmen, Mesut Aksakal, Mehmet Çay |
|---|---|
| Jazyk: | English<br />Spanish; Castilian |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Revista Científica, Vol 34, Iss 3 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0798-2259 2521-9715 |
| DOI: | 10.52973/rcfcv-e34436 |
| Popis: | The effect of thyroid gland on the male reproductive system (neonatal–prepubertal and adult periods) has been investigated for many years. Hypertyhroidism may cause male infertility by effecting spermatological parameters such as loss of motility and decreased of sperm concentration. However, the mechanisms of male infertility caused by hyperthyroidism are still not fully explained. The aim of this study was to investigate the effect of hyperthyroidism on testicular endoplasmic reticulum stress and the protein kinase RNA–like endoplasmic reticulum kinase (PERK) mediated antioxidant pathway in adult male rats. 24 Sprague Dawley adult male rats were used. Rats were divided into two groups: control group (received intraperitoneal injections of saline solution 1 mL·day-1 for 8 week) and hyperthyroidism group (received intraperitoneal injections of l–thyroxine 0,3 mg·kg-1·mL-1·day-1 for 8 week). The serum free triiodothyronine (fT3) (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|