| Autor: |
Chiaki Kato, Muneyuki Sekiya, Ryo Sekiguchi, Akira Yamasaki, Takahiro Yoshizawa, Kazutoshi Isobe, Naobumi Tochigi, Kazutoshi Shibuya, Kazuma Kishi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Respirology Case Reports, Vol 11, Iss 10, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2051-3380 |
| DOI: |
10.1002/rcr2.1217 |
| Popis: |
Abstract A 75‐year‐old woman was referred to our hospital because of a productive cough and an abnormal shadow on chest radiography. She was diagnosed as having metastatic lung adenocarcinoma harbouring ROS proto‐oncogene 1 (ROS1). First‐line therapy was instituted with entrectinib 600 mg daily, and a gradual decrease in serum sodium level was noticed on day 6, which deteriorated to Grade 3 hyponatremia on day 12. Despite a partial therapeutic response to entrectinib, she developed fatigue and dizziness, so the drug was withdrawn. The clinical findings and laboratory workup were compatible with a diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to entrectinib. The hyponatremia subsequently improved and entrectinib was resumed at a reduced dose of 400 mg daily, which has been continued to date, with no recurrence of SIADH. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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