Biological basis of immunomodulatory preparations using in treatment of multiple myeloma

Autor:	S. V. Semochkin
Jazyk:	ruština
Rok vydání:	2022
Předmět:	immunomodulatory preparations lenalidomide multiple myeloma activity mechanisms therapy Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Онкогематология, Vol 0, Iss 1, Pp 21-31 (2022)
Druh dokumentu:	article
ISSN:	1818-8346 2413-4023
Popis:	Immunomodulatory preparations (IMP) — lenalidomide (СС-5013, Revlimid®) and pomlidomide (CC-4047, Actimid®) — a new class of the medical products which are thalidomide synthetic derivatives. In comparison with initial compound they possess higher therapeutic activity and the optimized profile of toxic complications. In this review modern data on IMP antitumor activity with reference to multiple myeloma therapy are presented. Results of clinical study of lenalidomide in first-line therapy, in relapsed/refractory multiple myeloma and as a maintenance therapy after transplantation are shown.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/07c165437c0f45d8b8eb9e18aa14387d Zobrazit plný text záznamu View record in DOAJ