What can we learn from senescent platelets, their transcriptomes and proteomes?
| Autor: | Harriet E. Allan, Ami Vadgama, Paul C. Armstrong, Timothy D. Warner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Platelets, Vol 34, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0953-7104 1369-1635 09537104 |
| DOI: | 10.1080/09537104.2023.2200838 |
| Popis: | Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. However, these observations have largely been demonstrated in patient groups in which there may be underlying systemic changes that effect platelet function. Recent advances in technology have allowed in-depth analysis of differently aged platelets isolated from the peripheral blood of healthy individuals and have demonstrated that aged platelets, often referred to as senescent platelets, undergo extensive changes in the transcriptome and proteome. Ultimately, these changes result in platelets whose functions have deteriorated such that they cannot partake in hemostatic responses to the same extent as newly formed platelets. Here, we review transcriptomic and proteomic research in platelet aging in the context of health and how this research sheds light upon alterations in platelet structure and function. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|