| Autor: |
Dhineshkumar Manoharan, Kannan Kulanthai, Gnanavel Sadhasivam, Vijayan Raji, Paalvannan Thayumanavan |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 12, Iss 2 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| DOI: |
10.3329/bjp.v12i2.30872 |
| Popis: |
Series of indoline derivatives were synthesized using N-(4-aminophenyl)indoline-1-carbothiamide as a precursor. The confirmation of synthesized compounds was done by 1H-NMR, 13C-NMR, LC-MS (ESI) and FT-IR. In vitro antidiabetic activity of synthesized indoline derivatives were examined by standard ?-amylase inhibition assay. The compounds 4a (IC50 = 52.1 µg/mL) and 4b (IC50 = 57.7 µg/mL) showed potent ?-amylase inhibition activity. The compounds 3a (IC50 = 62.2 µg/mL) and 3b (IC50 = 60.7 µg/mL) showed moderate antidiabetic activity. Video Clip of Methodology: 19 min 21 sec Full Screen Alternate |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
