Adjuvant Radiation after Primary Resection of Atypical Lipomatous Tumors of the Extremity Reduces Local Recurrence but Increases Complications: A Multicenter Evaluation

Autor: Joshua M. Lawrenz, Samuel R. Johnson, Kevin Zhu, Mallory McKeon, Cullen P. Moran, Jose Vega, Katherine S. Hajdu, James P. Norris, Leo Y. Luo, Eric T. Shinohara, Justin M. M. Cates, Brian P. Rubin, John D. Reith, Jennifer L. Halpern, Nathan W. Mesko, Herbert S. Schwartz, Lukas M. Nystrom, Ginger E. Holt
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Sarcoma, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 1369-1643
DOI: 10.1155/2022/2091677
Popis: Background. Radiation after resection of an atypical lipomatous tumor (ALT) is controversial. This study evaluates local control and complications after the first resection of ALTs of the extremity with or without adjuvant radiation. Methods. A dual institution, retrospective review of patients treated from 1995 to 2020 with first-time resection of an ALT in the extremity was performed. In total, 102 patients underwent adjuvant radiation (XRT group) and 68 patients were treated with surgery alone (no-XRT group). The median follow-up time was 4.6 years (interquartile range (IQR) 2.0–7.3 years). The median radiation dose was 60 Gy (IQR 55–66 Gy). Univariable and multivariable analyses evaluated the association of patient, tumor, and treatment variables with recurrence and complications. Kaplan–Meier analysis evaluated local recurrence-free survival (LRFS) and time to complication. Results. The overall incidence of local recurrence was 1% (1/102) in the XRT group and 24% (16/68) in the no-XRT group p
Databáze: Directory of Open Access Journals
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