The Benign Clone Causing Aplastic Anaemia

Autor: Shaun R. McCann, Andrea Piccin
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Thalassemia Reports, Vol 13, Iss 2, Pp 157-164 (2023)
Druh dokumentu: article
ISSN: 2039-4365
DOI: 10.3390/thalassrep13020015
Popis: Severe Aplastic Anaemia (SAA) is a rare benign disease but carries a high-mortality rate unless treated in a specialised centre. Overwhelming laboratory and clinical evidence points to an autoimmune pathogenesis; although, the aetiology remains obscure in the majority of cases. The differential diagnosis in older patients is problematical and a diagnosis of hypoplastic myelodysplasia remains difficult. This review points out the difficulty in diagnosis without a specific test. Future research needs to define a specific diagnostic test and refine therapeutic interventions.
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