| Autor: |
Pia De Stefano, Eric Ménétré, Serge Vulliémoz, Pieter Van Mierlo, Margitta Seeck |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Clinical Neurophysiology Practice, Vol 7, Iss , Pp 279-284 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2467-981X |
| DOI: |
10.1016/j.cnp.2022.09.004 |
| Popis: |
Objective: To determine the influence of antiseizure medication (ASM) withdrawal on interictal epileptogenic discharges (IEDs) in scalp-EEG and seizure propensity. Methods: We included 35 adult unifocal epilepsy patients admitted for presurgical evaluation in the EEG and Epilepsy Unit of Geneva between 2016 and 2020, monitored for at least 5 days. ASM was individually tapered down, and automated IED detection was performed using Epilog PreOp (Epilog NV, Belgium, Ghent). We compared spike rate per hour (SR) at day 1 when patients were on full medication (baseline) with SR at the day with the lowest dose of medication. To determine possible peri-ictal changes of SR, we compared SR 8 h before and after a seizure with the SR at the same time of the baseline day. Results: Our results showed a significant increase in spiking activity in the day of lowest drug load if compared to spike rate at day on full medication (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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