Relationship between redox potential of glutathione and DNA methylation level in liver of newborn guinea pigs

Autor:	Angela Mungala Lengo, Clémence Guiraut, Ibrahim Mohamed, Jean-Claude Lavoie
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	smoflipid intralipid oxidative stress neonatal nutrition parenteral nutrition dna methylation Genetics QH426-470
Zdroj:	Epigenetics, Vol 15, Iss 12, Pp 1348-1360 (2020)
Druh dokumentu:	article
ISSN:	1559-2294 1559-2308 15592294
DOI:	10.1080/15592294.2020.1781024
Popis:	The metabolism of DNA methylation is reported to be sensitive to oxidant molecules or oxidative stress. Hypothesis: early-life oxidative stress characterized by the redox potential of glutathione influences the DNA methylation level. The in vivo study aimed at the impact of modulating redox potential of glutathione on DNA methylation. Newborn guinea pigs received different nutritive modalities for 4 days: oral nutrition, parenteral nutrition including lipid emulsion Intralipid (PN-IL) or SMOFLipid (PN-SF), protected or not from ambient light. Livers were collected for biochemical determinations. Redox potential (p 0.42; p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0775925acc3a4a808494cd164bbce32e Zobrazit plný text záznamu View record in DOAJ