Off-label Utilization of Antidepressants

Autor: Daniele Fabio Zullino, Bruno Schwartz, Romain Bilancioni, Pierre Baumann
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Acta Medica, Vol 51, Iss 1, Pp 19-24 (2008)
Druh dokumentu: article
ISSN: 18059694
1211-4286
1805-9694
DOI: 10.14712/18059694.2017.3
Popis: While antidepressant prescription rules are established for approved indications by large-scale studies, off-label utilization naturally often lacks the validation by large scientific databases, and is at its best based on expert consensus. The aim of the present survey was to study the prescription habits of hospital psychiatrists with regard to antidepressants, comparing patients treated for depressions and anxiety disorder with patients receiving off-label antidepressant treatment. Methods: Data on drug use for this study were based on 6 reference days from April 1999 to November 2001 in the 98- bed psychiatric hospital of the University of Lausanne, Switzerland. The drug prescriptions of 174 patients were assessed. Results: Whereas the diagnosis did not influence the choice between newer or older antidepressants, patients presenting an anxiety disorder were 4.5 times more likely (p
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