Prognostic impact of high sensitive troponin in predicting 30-day mortality among patients admitted to hospital with influenza

Autor: Yogesh Sharma, Chris Horwood, Angela Chua, Paul Hakendorf, Campbell Thompson
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 32, Iss , Pp 100682- (2021)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2020.100682
Popis: Background: Worldwide, seasonal influenza causes significant mortality and severe infections may cause cardiac injury. High-sensitive-troponins (hsTnT) are sensitive and specific markers of myocardial damage. This study investigated the prognostic impact of hsTnT on 30-day mortality in hospitalised influenza patients. Methods: This retrospective study included influenza patients ≥ 18 years, who had hsTnT performed during admission in two tertiary-hospitals in South Australia. Diagnosis of influenza was confirmed by polymerase–chain-reaction (PCR) test and hsTnT > 14 ng/L with a change of > 20% during admission was considered to be indicative of acute-cardiac injury. Clinical characteristics, complications and 30-day mortality were compared among four groups of patients: hsTnT unavailable, hsTnT negative, chronically elevated hsTnT and acutely elevated hsTnT. Cox-proportional hazard regression determined the hazard of death at 30-days following hospital discharge after adjustment for co-variates. Results: Between January 2016 -March 2020, 1828 influenza patients, mean age 66.4 years, were hospitalised. Troponin results were available for 617 (47.7%) patients, of whom, 62 (10%) had acute myocardial injury and 232 (37.6%) had chronic hsTnT elevation. Both inpatient and 30-day mortality were significantly higher among patients with acute (P
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