Early origins of lung disease: towards an interdisciplinary approach

Autor: Niki D.J. Ubags, Miguel A. Alejandre Alcazar, Suhas G. Kallapur, Sylvia Knapp, Sophie Lanone, Clare M. Lloyd, Rory E. Morty, Céline Pattaroni, Niki L. Reynaert, Robbert J. Rottier, Hermelijn H. Smits, Wouter A.A. de Steenhuijsen Piters, Deborah H. Strickland, Jennifer J.P. Collins
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: European Respiratory Review, Vol 29, Iss 157 (2020)
Druh dokumentu: article
ISSN: 0905-9180
1600-0617
16000617
DOI: 10.1183/16000617.0191-2020
Popis: The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019).
Databáze: Directory of Open Access Journals
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