Synthesis of New Cisplatin Derivatives from Bile Acids

Autor:	Barbara Seroka, Zenon Łotowski, Agnieszka Hryniewicka, Lucie Rárová, Rafal R. Sicinski, Aneta M. Tomkiel, Jacek W. Morzycki
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	bile acids lithocholic acid deoxycholic acid hyodeoxycholic acid cholic acid steroidal diamines platinum(ii) complexes Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 3, p 655 (2020)
Druh dokumentu:	article
ISSN:	1420-3049 25030655
DOI:	10.3390/molecules25030655
Popis:	A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ced0752183f4482ea6ce97e0506049c8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF