First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India

Autor: Aniruddha Jakharia, Biswajyoti Borkakoty, Sumi Pait, Gautam Baruah, Rahul Hazarika, Dipankar Biswas
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Indian Journal of Pathology and Microbiology, Vol 67, Iss 1, Pp 133-139 (2024)
Druh dokumentu: article
ISSN: 0377-4929
0974-5130
DOI: 10.4103/ijpm.ijpm_748_21
Popis: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) responsible for the current pandemic has resulted in over 5 million deaths globally. More than a year has passed, still SARS-CoV-2 panic the public life. Virus isolation is of paramount importance for development of vaccines, in-vitro screening of antiviral compounds, pathogenesis studies, etc., Many cell lines were studied for amplification and replication of SARS-CoV-2 and Vero cells were found to be ideal cell lines for isolation. In May 2020, ICMR-Regional Medical Research Centre, NE region, India, successfully established the SARS-CoV-2 culture system in Vero CCL-81 cell lines. Phylogenetic analyses of the whole genome sequences of the SARS-CoV-2 isolate (EPI_ISL_2501532 | 2020-05-19) showed monophyletic clade G and lineage B.1.1.
Databáze: Directory of Open Access Journals
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