The Involvement of Microglial Cells in Japanese Encephalitis Infections

Autor: Thananya Thongtan, Chutima Thepparit, Duncan R. Smith
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Clinical and Developmental Immunology, Vol 2012 (2012)
Druh dokumentu: article
ISSN: 1740-2522
1740-2530
DOI: 10.1155/2012/890586
Popis: Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
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