The Involvement of Microglial Cells in Japanese Encephalitis Infections
Autor: | Thananya Thongtan, Chutima Thepparit, Duncan R. Smith |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: | |
Zdroj: | Clinical and Developmental Immunology, Vol 2012 (2012) |
Druh dokumentu: | article |
ISSN: | 1740-2522 1740-2530 |
DOI: | 10.1155/2012/890586 |
Popis: | Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. |
Databáze: | Directory of Open Access Journals |
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