Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats
| Autor: | Ismael H. Mohammed, Ismail S. Kakey, Mahdi M. Farimani |
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| Jazyk: | Arabic<br />English |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Iraqi Journal of Veterinary Sciences, Vol 34, Iss 1, Pp 109-113 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1607-3894 2071-1255 |
| DOI: | 10.33899/ijvs.2019.125557.1076 |
| Popis: | Prosopis farctais belonged to Mimosaceae family, commonly known as mesquite. It was chosen to investigate their effect on α-glucosidase inhibitory activity (in-vitro), serum glucose and liver functions. Roots, fruits, and leaves of P. farcta, were extracted by n-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC50 was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of P. farcta showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with P. farcta extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of P. farcta showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of P. farcta showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the P. farcta extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions. |
| Databáze: | Directory of Open Access Journals |
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