Association of MTHFR C677T, MTHFR A1298C polymorphism in relation to patients with autism in Thi-Qar Governorate
| Autor: | Roaa M. Nashee, Lamees M. Al-Janabi, Mohammed A. Altahan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Romanian Journal of Neurology, Vol 23, Iss 2, Pp 166-170 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1843-8148 2069-6094 |
| DOI: | 10.37897/RJN.2024.2.13 |
| Popis: | Background. Recent data suggests that environmental factors may account for up to 40-50% of the variability in the risk of developing autism spectrum disorder (ASD). Aim. The purpose of this study was to examine the correlation between MTHFR polymorphism and the heightened susceptibility to autism in children with autism in Thi-Qar. Material and method. A comparison case-control study of blood samples collected from a cohort of 100 individuals diagnosed with autism, along with 100 healthy individuals serving as a control group. The participants were divided into two groups. The first group, known as the control group, consisted of one hundred healthy people aged between 3 and 14 years. The second group consisted of one hundred autistic patients, ranging in age from 3 to 14 years old. Results. The findings demonstrated a noteworthy elevation in the gene expression of MTHFR C677T and MTHFR A1298C in all groups of patients, in comparison to the control group. The current study showed a significant difference at p-value < 0.05 was recorded the highest genotype was CT in autism patients 85% and in control group 1.43%, while the lowest genotype was TT 5% in autism patients, and in the control group 1.43%. Within the haplotype, a non-significant difference was noted at p-value |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|