| Autor: |
Geovani de Oliveira Ribeiro, Antonio Charlys da Costa, Danielle Elise Gill, Edcelha Soares D’Athaide Ribeiro, Marlisson Octavio da S. Rego, Fred Julio Costa Monteiro, Fabiola Villanova, Juliana Silva Nogueira, Adriana Yurika Maeda, Renato Pereira de Souza, Roozbeh Tahmasebi, Vanessa S. Morais, Ramendra Pati Pandey, V. Samuel Raj, Sirle Abdo Salloum Scandar, Fernanda Gisele da Silva Vasami, Leandro Guaraglia D’Agostino, Paulo César Maiorka, Xutao Deng, Maurício Lacerda Nogueira, Ester Cerdeira Sabino, Eric Delwart, Élcio Leal, Mariana Sequetin Cunha |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-83879-6 |
| Popis: |
Abstract Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3′UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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