Association between vitamin D receptor polymorphism and breast cancer in women: An umbrella review of meta-analyses of observational investigations

Autor: Yaxing Li, Junqin Zhang, Fei Tian, Paniz Anvarifard, Na Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Experimental Gerontology, Vol 194, Iss , Pp 112502- (2024)
Druh dokumentu: article
ISSN: 1873-6815
DOI: 10.1016/j.exger.2024.112502
Popis: This study aimed to conduct an umbrella review of meta-analyses to synthesize the existing evidence regarding the relationship between vitamin D receptor (VDR) polymorphism and breast cancer (BC) risk. A comprehensive search was performed across multiple databases, including Embase, PubMed, Scopus, the Cochrane Database of Systematic Reviews, and the Web of Science. The investigation included 17 meta-analyses for the BsmI polymorphism, 6 for the Cdx2 polymorphism, and 6 for the Poly (A) polymorphism. Among the 119 datasets analyzed, only 6 (5 %) reported statistically significant outcomes (p
Databáze: Directory of Open Access Journals