Autor: |
Myrianni Constantinou, James Nicholson, Xinyu Zhang, Eleni Maniati, Sara Lucchini, Gabriel Rosser, Claire Vinel, Jun Wang, Yau Mun Lim, Sebastian Brandner, Sven Nelander, Sara Badodi, Silvia Marino |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Cell Reports, Vol 43, Iss 6, Pp 114309- (2024) |
Druh dokumentu: |
article |
ISSN: |
2211-1247 |
DOI: |
10.1016/j.celrep.2024.114309 |
Popis: |
Summary: Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineage specification in glioblastoma, with an impact on both tumor size and invasiveness. Single-cell transcriptomic analysis of these tumors and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B reveal a regulatory role for the gene in the neural stem cell-to-astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via post-translational modifications of histone marks. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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