Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report

Autor:	Marc Weiner, Robert Rodriguez-Vigouroux, Stavroula Masouridi-Levrat, Kaveh Samii
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	COVID-19 Vaccine Immune thrombocytopenia SARS-CoV-2 Splenectomy Case report Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Thrombosis Journal, Vol 20, Iss 1, Pp 1-4 (2022)
Druh dokumentu:	article
ISSN:	1477-9560
DOI:	10.1186/s12959-022-00404-z
Popis:	Abstract Background Some conventional vaccines have been recognized as a cause of secondary immune thrombocytopenia (ITP). According to recent publications, mRNA vaccines are probably associated with an increased risk of ITP. Case presentation Our patient developed severe ITP one week after the second dose of COVID-19 mRNA vaccine. Medical management was not effective, requiring splenectomy to obtain sustained remission. Conclusion Considering the temporality and immunological hypothesis, we consider the vaccine to be the trigger of this ITP. To our knowledge, our case is, to date, the most severe case of ITP reported following SARS-CoV-2 vaccination and could help for the therapeutic management of similar patients.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/06d80d70b10240c8a50d0596d3fc14ee Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.