Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database

Autor:	Mamta Puraswani, Priyanka Khandelwal, Himanshi Saini, Savita Saini, Bahadur Singh Gurjar, Aditi Sinha, Rajashri Pramod Shende, Tushar Kanti Maiti, Abhishek Kumar Singh, Uma Kanga, Uma Ali, Indira Agarwal, Kanav Anand, Narayan Prasad, Padmaraj Rajendran, Rajiv Sinha, Anil Vasudevan, Anita Saxena, Sanjay Agarwal, Pankaj Hari, Arvind Sahu, Satyajit Rath, Arvind Bagga
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	atypical hemolytic uremic syndrome factor H plasma exchange renal reserve thrombotic microangiopathy Immunologic diseases. Allergy RC581-607
Zdroj:	Frontiers in Immunology, Vol 10 (2019)
Druh dokumentu:	article
ISSN:	1664-3224 37252232
DOI:	10.3389/fimmu.2019.01282
Popis:	Background: Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well with disease activity and their functional characterization is required.Methods: Of 781 patients
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/06c62aefba2147c6be52a9d372522328 Zobrazit plný text záznamu View record in DOAJ