Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis
| Autor: | Riezzo Giuseppe, Orlando Antonella, Clemente Caterina, D’Attoma Benedetta, Valentini Anna Maria, Armentano Raffaele, Giorgio Pietro, Pisani Antonio, Russo Francesco |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Archives of Biological Sciences, Vol 73, Iss 3, Pp 331-339 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0354-4664 1821-4339 21041202 |
| DOI: | 10.2298/ABS210412026R |
| Popis: | Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestinal (GI) diseases, we aimed to evaluate TG2 and inflammatory markers’ mucosal content in gastric antrum biopsies to shed light on the histological and biochemical background of chronic gastritis inflammation. Fifty-one of 78 patients who underwent upper GI endoscopy (UGIE) for dyspeptic symptoms, had a gastric biopsy. The symptom profile was assessed by a GI symptom rating scale (GSRS) score. Thirty-five patients (69%) showed chronic gastritis. TG2, interleukin-6 (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, lipopolysaccharides (LPS) and toll-like receptor (TLR)-4 were evaluated in serum and the culture medium of gastric biopsies. TG2, IL-8, IL-10, TLR-4 and TNF-α were significantly higher in active chronic gastritis than in the inactive one and were linked to macrophage concentration. IL-6 was significantly lower in the active form of chronic gastritis than in the inactive one and negatively correlated with TG2. Lastly, IL-10 significantly correlated with the macrophage score. TG2 can exert an active role in chronic gastritis pathogenesis by cooperating with different markers of inflammation. It seems that TG2 can represent a possible therapeutic target for modulating inflammation and disease progression. |
| Databáze: | Directory of Open Access Journals |
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