A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies

Autor: Hui Ming, Kunpeng Zhang, Shengbo Ge, Yang Shi, Chunan Du, Xuqiang Guo, Libo Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nanomaterials, Vol 13, Iss 2, p 224 (2023)
Druh dokumentu: article
ISSN: 2079-4991
DOI: 10.3390/nano13020224
Popis: As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
Databáze: Directory of Open Access Journals