Microarrays. The bridges in the knowledge of mental retardarion diagnosed in childhood
| Autor: | Márquez González Horacio, Márquez Flores Horacio, Camarillo Blancarte Leyla |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Acta Pediátrica de México, Vol 34, Iss 5, Pp 275-279 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0186-2391 2395-8235 |
| DOI: | 10.18233/APM34No5pp275-279 |
| Popis: | Mental retardation (MR), is a common neurological condition in children. Its etiology may be genetic or environmental. In the first case, all the disorders that cause it have not been identified and a considerable number of patients do not have an accurate diagnosis. Microarrays are derived from comparative genomic hybridiza- tion (CGH), which can determine sites of deletions, insertions or translocations. This technique has made it possible to determine chromosomal syndromes not previously described such as: 17q21.31 deletion, deletion 15q24 or 1q21 deletion. It can be done in large populations or be individualized. The intro- duction of this technique has begun to resolve doubts regarding monogenic or polygenic RMI. |
| Databáze: | Directory of Open Access Journals |
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