| Autor: |
Yuan Luo, Wenhao Zhou, Ruixin Li, Samwel M. Limbu, Fang Qiao, Liqiao Chen, Meiling Zhang, Zhen-Yu Du |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Animal Nutrition, Vol 11, Iss , Pp 25-37 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6545 |
| DOI: |
10.1016/j.aninu.2022.06.011 |
| Popis: |
Pyruvate dehydrogenase kinases (PDKs)-pyruvate dehydrogenase E1α subunit (PDHE1α) axis plays an important role in regulating glucose metabolism in mammals. However, the regulatory function of PDKs-PDHE1α axis in the glucose metabolism of fish is not well known. This study determined whether PDKs inhibition could enhance PDHE1α activity, and improve glucose catabolism in fish. Nile tilapia fingerlings (1.90 ± 0.11 g) were randomly divided into 4 treatments in triplicate (30 fish each) and fed control diet without dichloroacetate (DCA) (38% protein, 7% lipid and 45% corn starch) and the control diet supplemented with DCA, which inhibits PDKs through binding the allosteric sites, at 3.75 (DCA3.75), 7.50 (DCA7.50) and 11.25 g/kg (DCA11.25), for 6 wk. The results showed that DCA3.75, DCA7.50 and DCA11.25 significantly increased weight gain, carcass ratio and protein efficiency ratio (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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