| Autor: |
Kara Ozlem, Yakan Birkan, Kara Mustafa, Kaymak Emin |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Taiwanese Journal of Obstetrics & Gynecology, Vol 57, Iss 6, Pp 836-841 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1028-4559 |
| DOI: |
10.1016/j.tjog.2018.10.012 |
| Popis: |
Objective: It is aimed to evaluate the protective effect of bilberry on I/R injury in rat ovary. Materials and methods: A total 48 female Wistar–Albino rats were utilized to form five groups: Group 1 (control group) (n = 8), neither drug was given and nor procedure was performed. Group 2 (bilberry control group) (n = 10), single dose 200 mg/kg bilberry was administered by gavage and no procedure was performed. Group 3 (I/R group) (n = 10), no drug was given, 1-h ischemia and 2-h reperfusion was performed. Group 4 (bilberry before I/R group) (n = 10), single dose 200 mg/kg bilberry was administered by gavage before ischemia. Then 1-h ischemia and 2-h reperfusion was performed. Group 5 (bilberry after I/R group) (n = 10), first 1-h ischemia was performed. Single dose 200 mg/kg bilberry was administered by gavage and then 2-h reperfusion was performed. Right ovaries were surgically extirpated in all groups. In ovarian tissue samples, malondialdehyde (MDA) levels and enzymatic activities of superoxide dismutase (SOD), catalase (CAT) were studied. In ovarian tissue samples, DNA damage and apoptosis were assessed by using TUNEL method. Histopathologic examination was performed by light microscopic findings. Results: When group 3 was compared with another groups, MDA levels were significantly higher, enzymatic activities of SOD and CAT were found to be as significantly lower in ovarian tissue and blood (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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