Diagnostic Utility of Integration of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MR Perfusion Employing Split Bolus Technique in Differentiating High-Grade Glioma

Autor:	Virender Malik, Chandrasekharan Kesavadas, Bejoy Thomas, Deepti A. N., Krishna Kumar K.
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	combined perfusion technique split bolus contrast grade III from grade IV glioma Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	Indian Journal of Radiology and Imaging, Vol 34, Iss 03, Pp 382-389 (2024)
Druh dokumentu:	article
ISSN:	0971-3026 1998-3808
DOI:	10.1055/s-0043-1777742
Popis:	Background: Despite documented correlation between glioma grades and dynamic contrast-enhanced (DCE) magnetic resonance (MR) perfusion-derived parameters, and its inherent advantages over dynamic susceptibility contrast (DSC) perfusion, the former remains underutilized in clinical practice. Given the inherent spatial heterogeneity in high-grade diffuse glioma (HGG) and assessment of different perfusion parameters by DCE (extravascular extracellular space volume [Ve] and volume transfer constant in unit time [k-trans]) and DSC (rCBV), integration of the two into a protocol could provide a holistic assessment. Considering therapeutic and prognostic implications of differentiating WHO grade 3 from 4, we analyzed the two grades based on a combined DCE and DSC perfusion.
Databáze:	Directory of Open Access Journals
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