Temporal and compartment-specific signals coordinate mitotic exit with spindle position

Autor: Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop, Gislene Pereira
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14129
Popis: The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors.
Databáze: Directory of Open Access Journals