Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics

Autor: Amin Amirouche, Rosaria Ferrigno, Magalie Faivre
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Proceedings, Vol 1, Iss 4, p 512 (2017)
Druh dokumentu: article
ISSN: 2504-3900
DOI: 10.3390/proceedings1040512
Popis: In this work, we aimed at the discrimination of mechanically impaired red blood cells (RBCs) using passive microfluidic approaches. We investigated the impact of the channel geometry on the behavior of healthy RBCs (hRBCs) and thermally rigidified RBCs (T-rRBCs) flowing in (i) a Unique and Long Constriction (ULC) and (ii) a series of Oscillating Width Constrictions (OWC). To confront the two geometries, we evaluated potential biomarkers for cell discrimination such as their speed V, deformation index D and relaxation time τ.
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