Ocular changes in metastatic melanoma patients treated with MEK inhibitor cobimetinib and BRAF inhibitor vemurafenib

Autor: Gavric Ana Ursula, Ocvirk Janja, Mekjavic Polona Jaki
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Radiology and Oncology, Vol 52, Iss 2, Pp 213-219 (2018)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2018-0002
Popis: Mitogen-activated protein kinase kinase (MEK) inhibitor cobimetinib and V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitor vemurafenib have significantly improved the prognosis of BRAF-mutated metastatic melanoma. Some ocular symptoms and signs were recently recognized to follow this treatment. The study was aimed to investigate ocular toxicity in patients with metastatic melanoma treated with cobimetinib in combination with vemurafenib.
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