Response to inhaled ceftazidime in patients with non‐cystic fibrosis bronchiectasis and chronic bronchial infection unrelated to Pseudomonas aeruginosa

Autor: Vanessa Riveiro, Ana Casal, José M. Álvarez‐Dobaño, Tamara Lourido, Pedro Suárez‐Artime, Carlota Rodríguez‐García, Lucía Ferreiro, María E. Toubes, Luis Valdés
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 16, Iss 11, Pp 768-773 (2022)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13534
Popis: Abstract Introduction Inhaled antibiotics reduce the frequency of exacerbations. The objective was to assess the efficacy of inhaled ceftazidime in patients with non‐cystic fibrosis bronchiectasis (NCFB) and concomitant chronic bronchial infection (CBI) caused by potentially pathogenic microorganisms (PPM) other than Pseudomonas aeruginosa (PA). Material and Method Quasi‐experimental study in 21 patients with exacerbations who developed CBI by a PPM other than PA. Results Bacterial infection was resolved in 85.7% patients. Rehospitalizations, length of hospital stay, moderate exacerbations and blood levels of CRP decreased significantly. In addition, SGRQ questionnaire also decreased more than 4 points in 57.1% of the patients. Conclusion The results suggest that inhaled ceftazidime in NCFB unrelated to PA is a plausible alternative to the standard therapies used in clinical practice.
Databáze: Directory of Open Access Journals
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