Impact of bacterial infections prior to liver transplantation on post-transplant outcomes in patients with cirrhosis

Autor: Simone Incicco, Marta Tonon, Nicola Zeni, Carmine Gambino, Roberta Gagliardi, Valeria Calvino, Anna Barone, Gianluca Zilio, Paolo Feltracco, Patrizia Burra, Umberto Cillo, Paolo Angeli, Salvatore Piano
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: JHEP Reports, Vol 5, Iss 9, Pp 100808- (2023)
Druh dokumentu: article
ISSN: 2589-5559
DOI: 10.1016/j.jhepr.2023.100808
Popis: Background & Aims: Bacterial infections are frequent in patients with cirrhosis and increase the risk of death and drop-out from liver transplant (LT) waiting list. In patients with bacterial infections, LT is frequently delayed because of the fear of poor outcomes. We evaluated the impact of pre-LT infections on post-LT complications and survival. Methods: From 2012 to 2018, consecutive patients transplanted at the Hospital of Padua were identified and classified in two groups: patients surviving an episode of bacterial infection within 3 months before LT (study group) and patients without infections before LT (control group). Post-LT outcomes (complications, new infections, survival) were collected. Results: A total of 466 LT recipients were identified (study group n = 108; control group n = 358). After LT, the study group had a higher incidence of new bacterial (57% vs. 20%, p
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