Anticonvulsant effect of ethanolic extract of Cyperus articulatus L. leaves on pentylenetetrazol induced seizure in mice

Autor: Oscar Herrera-Calderon, Rocio Santiváñez-Acosta, Bertha Pari-Olarte, Edwin Enciso-Roca, Vicente Martin Campos Montes, Jorge Luis Arroyo Acevedo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Traditional and Complementary Medicine, Vol 8, Iss 1, Pp 95-99 (2018)
Druh dokumentu: article
ISSN: 2225-4110
DOI: 10.1016/j.jtcme.2017.03.001
Popis: Cyperus articulatus (CA) rhizomes have demonstrated different properties on nervous system. However, the leaves still have not studied to treat epilepsy. The aim of this study was to determine the effect of CA ethanolic extract on pentylenetetrazol (PTZ) induced seizures in mice as well as measuring its antioxidant activity in vivo and in vitro. Mice were divided into five groups: (1) control (PTZ 80 mg/kg; i.p.), (2) PTZ-Diazepam (1 mg/kg; i.p.), (3–5) PTZ-CA 50, PTZ-CA 150 and PTZ-CA 300 (50, 150 and 300 mg/kg of CA extract, 30 min prior to each PTZ injection). The PTZ-CA 150 group showed lower seizure scores (P
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