Survival and control prognosticators of recurrent gynecological malignancies of the pelvis and para-aortic region treated with stereotactic body radiation therapy (SBRT)

Autor: Shaakir Hasan, Anthony Ricco, Kaylette Jenkins, Rachelle Lanciano, Alexandra Hanlon, John Lamond, Jun Yang, Jing Feng, Michael Good, Joel Noumoff, Luther Brady
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Frontiers in Oncology, Vol 6 (2016)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2016.00249
Popis: Abstract: Purpose: To define prognostic factors associated with improved survival and local control for gynecologic cancer recurrences limited to the pelvis and para-aortic region using stereotactic body radiation therapy (SBRT).Methods: Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n=12), cervical (n=11), ovarian (n=3), uterine serous (n=2) or carcinosarcoma (n=2) CA were treated with SBRT. Eleven recurrences were located in the central pelvis(CP), 11 along the pelvic sidewall(PSW), and 13 in the para-aortic (PA)region.Results: Five-year survival for all patients was 42% with a median survival of 43.4 months. Multivariate analysis revealed better performance status (PS) and smaller clincial tumor volume (CTV) were significant for improved survival (P
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