The Alteration of HDL in Patients with AMI Inhibited Angiogenesis by Blocking ERK1/2 Activation

Autor: Wei Zhang, Zhe Li, Wen-Qi Han, Qun-Rang Wang, Hao-Yu Wu, Xin-Hong Liu, Kun Xing, Gong Cheng, Feng-Jun Chang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cardiovascular Therapeutics, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 1755-5922
DOI: 10.1155/2022/1057772
Popis: Objective. High-density lipoprotein (HDL) was found vasoprotective, but numbers of patients with acute myocardial infarction (AMI) have normal or even high levels of pathological HDL (pHDL). So, we investigate the mechanism of pHDL in AMI patients on angiogenesis. Methods. HDL with normal levels from healthy subjects (nHDL, control group, n=20) and patients with AMI (pHDL, experimental groups, n=30) were obtained by super high speed centrifugation. Then, effects of HDL on proliferation, migration, angiogenesis, and expression of ERK1/2 and its phosphorylation in human umbilical vein endothelial cells (HUVEC) with or without PD98059 (inhibitor of ERK1/2) preincubation were detected. Results. Compared with the control group (nHDL), HDL from the experimental group (pHDL) significantly inhibited the phosphorylation of ERK1/2, proliferation, migration, and angiogenesis of HUVEC (P
Databáze: Directory of Open Access Journals
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