| Autor: |
V. Vandhana, K. Vishwas Saralaya, Sevitha Bhat, Shalini Shenoy Mulki, Archana. K. Bhat |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Microbiology, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1687-9198 |
| DOI: |
10.1155/2022/4532707 |
| Popis: |
Introduction. Hypervirulent K. pneumoniae (Hv-Kp) is an emerging variant of classical K. pneumoniae (C-Kp) that exhibits hypermucoviscocity and possesses multiple siderophores as virulence factors and is known to cause serious debilitating infections in immunocompetent individuals. Aim and objective. The aim of this study is to identify C-Kp and Hv-Kp strains and detect their virulence factors and antimicrobial susceptibility patterns. Materials and Methods. A total of 129 K. pneumoniae isolates from different clinical samples were used for the identification and differentiation of classical K. pneumoniae (C-Kp) and hypervirulent K. pneumoniae (Hv-Kp) to correlate their virulence with antimicrobial susceptibility patterns and identify their risk factors. Hypermucoviscosity was determined by a string test (>5 mm of string length). The aerobactin gene was detected by PCR. Results and Conclusion. In total, 13.9% (18/129) were Hv-Kp and 86.1% (111/129) were C-Kp. Only 50% (9/18) of the Hv-Kp isolates were hypermucoviscous. C-Kp was significantly more resistant to antimicrobials than Hv-Kp. Among C-Kp, 75.7% were ESBL producers and 76.6% were multidrug resistant while in Hv-Kp, 44.44% were both ESBL producers and multidrug-resistant which is statistically significant (P |
| Databáze: |
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