Effects of adenosine and regadenoson on hemodynamics measured using cardiovascular magnetic resonance imaging

Autor: Dustin M. Thomas, Matthew R. Minor, James K. Aden, Christopher J. Lisanti, Kevin E. Steel
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-10 (2017)
Druh dokumentu: article
ISSN: 1532-429X
54502802
DOI: 10.1186/s12968-017-0409-8
Popis: Abstract Background Adenosine or regadenoson vasodilator stress cardiovascular magnetic resonance (CMR) is an effective non-invasive strategy for evaluating symptomatic coronary artery disease. Vasodilator injection typically precedes ventricular functional sequences to efficiently reduce overall scanning times, though the effects of vasodilators on CMR-derived ventricular volumes and function are unknown. Methods We prospectively enrolled 25 healthy subjects to undergo consecutive adenosine and regadenoson administration. Short axis CINE datasets were obtained on a 1.5 T scanner following adenosine (140mcg/kg/min IV for 6 min) and regadenoson (0.4 mg IV over 10 s) at baseline, immediately following administration, at 5 min intervals up to 15 min. Hemodynamic response, bi-ventricular volumes and ejection fractions were determined at each time point. Results Peak heart rate was observed early following administration of both adenosine and regadenoson. Heart rate returned to baseline by 10 min post-adenosine while remaining elevated at 15 min post-regadenoson (p = 0.0015). Left ventricular (LV) ejection fraction (LVEF) increased immediately following both vasodilators (p
Databáze: Directory of Open Access Journals
Externí odkaz: