MORPHOFUNCTIONAL CHANGES OF THE MYOENDOCRINE ATRIAL CELLS AT POSTRESECTION PORTAL HYPERTENSION
| Autor: | Hnatjuk M. S., Tatarchuk L. V., Hdanska N. M. |
|---|---|
| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Вісник проблем біології і медицини, Vol 1, Iss 4, Pp 218-220 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2077-4214 2523-4110 |
| DOI: | 10.29254/2077-4214-2019-4-1-153-218-220 |
| Popis: | In recent years, the number of scientific works devoted to endocrine function of the heart has been increasing in the biomedical literature. It is known that in some atrial cells secretory granules are found that contain atrial natriuretic hormone. Most researchers named these specialized cardiomyocytes as myoendocrine cells in the atria or myoendocrine cardiomyocytes. It is also known that myoendocrine atrial cardiomyocytes respond promptly and pronouncedly to changes in the internal and external environment, providing the necessary stable level of physiological and biochemical processes in the body. Morphological aspects of the state of the endocrine apparatus of the heart have been studied in various physiologica and pathological conditions. At the same time, the features of secretory activity of atrial cardiomyocytes at postresection portal hypertension were not investigated. The purpose of the research – morphological study of peculiarities of changes of atrial myendocrine cells under conditions at postresection portal hypertension. Object and methods. A complex of morphological methods investigated myoendocrine cells of the atria of 45 laboratory adult white male rats, which were divided into 3 groups. The group 1consisted of 15 intact animals that were in normal vivarium conditions, 2-15 rats after resection of the left lateral lobe – 31.5% of the liver parenchyma, 3-15 animals after resection of the right and left lateral lobes of the liver (58,1%). Euthanasia of experimental animals was performed by bloodletting in codition of thiopental anesthesia 1 month after the beginning of the experiment. The relative volumes of secretory granules of the left and right of the atria and the percentages of young, mature and diffusing secretory granules were determined stereometrically on the electronograms. Quantitative indicators were processed statistically. Results and discussion. Resection of 58.1% of the liver parenchyma led to the development of postresection portal hypertension and changes the secretory activity of myoendocrine atrial cells. Thus, the relative volume of secretory granules in the left atrium with postresection portal hypertension decreased statistically (p |
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