Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation

Autor: Zhengsong Wang, Zhen Pan, Dakuo He, Jiahui Shi, Shouxin Sun, Yue Hou
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Complexity, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 1076-2787
1099-0526
DOI: 10.1155/2019/3659309
Popis: The pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry. The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process design, analysis, control, and optimization. So the simulation modeling for PTMP via wet granulation is very necessary and significant. This study aims at proposing a simulation modeling framework for PTMP via spray fluidized bed granulation (SFBG), which is one of the most widely used wet granulation techniques in pharmaceutical industry. For SFBG, a simulation model that simultaneously involves the influences of operating variables and material attributes on average particle size (APS) is firstly developed, and then a drying model to determine the particle moisture content is introduced to be coupled with the established model predicting APS. For PTMP, considering the important effect of porosity on tablet qualities, a model describing the changes in tablet porosity is developed based on a promoted form of the Heckel equation, and then several recognized models that are all related to porosity are introduced or constructed to calculate important tablet quality indexes. The feasibility and effectiveness of the developed simulation models are validated by performing a computational experimental study to explore the scientific understanding of process and process quality control.
Databáze: Directory of Open Access Journals
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