| Autor: |
Spencer Flynn, Jacqueline Leete, Pashtun Shahim, Cassandra Pattinson, Vivian A. Guedes, Chen Lai, Christina Devoto, Bao-Xi Qu, Kisha Greer, Brian Moore, Andre van der Merwe, Vindhya Ekanayake, Jessica Gill, Leighton Chan |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-82875-0 |
| Popis: |
Abstract Traumatic brain injury (TBI) is linked to long-term symptoms in a sub-set of patients who sustain an injury, but this risk is not universal, leading us and others to question the nature of individual variability in recovery trajectories. Extracellular vesicles (EVs) are a promising, novel avenue to identify blood-based biomarkers for TBI. Here, our aim was to determine if glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) measured 1-year postinjury in EVs could distinguish patients from controls, and whether these biomarkers relate to TBI severity or recovery outcomes. EV GFAP and EV NfL were measured using an ultrasensitive assay in 72 TBI patients and 20 controls. EV GFAP concentrations were elevated in moderate and severe TBI compared to controls (p’s |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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