Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial.
| Autor: | Marcus May, Faikah Gueler, Hannelore Barg-Hock, Karl-Heinz Heiringhoff, Stefan Engeli, Karsten Heusser, André Diedrich, André Brandt, Christian P Strassburg, Jens Tank, Fred C G J Sweep, Jens Jordan |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 6, Iss 10, p e25898 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 74630911 |
| DOI: | 10.1371/journal.pone.0025898 |
| Popis: | Water drinking acutely increases sympathetic activity in human subjects. In animals, the response appears to be mediated through transient receptor potential channel TRPV4 activation on osmosensitive hepatic spinal afferents, described as osmopressor response. We hypothesized that hepatic denervation attenuates water drinking-induced sympathetic activation. We studied 20 liver transplant recipients (44±2.6 years, 1.2±0.1 years post transplant) as model of hepatic denervation and 20 kidney transplant recipients (43±2.6 years, 0.8±0.1 years post transplant) as immunosuppressive drug matched control group. Before and after 500 ml water ingestion, we obtained venous blood samples for catecholamine analysis. We also monitored brachial and finger blood pressure, ECG, and thoracic bioimpedance. Plasma norepinephrine concentration had changed by 0.01±0.07 nmol/l in liver and by 0.21±0.07 nmol/l in kidney transplant recipients (p |
| Databáze: | Directory of Open Access Journals |
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