The role of epithelial alarmins and Th2 cytokines in the inflammatory response in allergic rhinitis
| Autor: | V. V. Makarevich, A. D. Taganovich, T. V. Mironova, I. P. Shilovskiy, M. R. Khaitov, A. G. Kadushkin |
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| Jazyk: | ruština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Сибирский научный медицинский журнал, Vol 44, Iss 5, Pp 35-45 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2410-2512 2410-2520 |
| DOI: | 10.18699/SSMJ20240504 |
| Popis: | Allergic rhinitis (AR) occupies a leading position among the causes of morbidity throughout the world, to date, it has been diagnosed in 400 million people. In the formation and progression of AR, a significant role is assigned to cytokines associated with the second type of immune response, in particular, IL-4, IL-5, IL-9, IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP). This literature review provides information on the influence of the listed mediators on the structural cells of the nasal cavity and blood immune cells (T- and B-lymphocytes, eosinophils, macrophages, dendritic cells), and discusses their association with the manifestation of AR symptoms and the severity of the disease. The results of studies aimed at establishing the level of IL-4, IL-5, IL-9, IL-13, IL-25, IL-33 and TSLP in biological fluids (blood serum, nasal lavage) and their expression in nasal epithelial cells in patients with AR compared to healthy people are assessed. |
| Databáze: | Directory of Open Access Journals |
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