Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
| Autor: | Taysa Ribeiro Schalcher, Jose Luiz Fernandes Vieira, Claudio Guedes Salgado, Rosivaldo dos Santos Borges, Marta Chagas Monteiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 46, Iss 5, Pp 645-649 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1678-9849 0037-8682 |
| DOI: | 10.1590/0037-8682-1506-2013 |
| Popis: | Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. |
| Databáze: | Directory of Open Access Journals |
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