GENERAL CHARACTERISTICS AND FAMILIAL AGGREGATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
| Autor: | Madalina-Pusa Duna, Denisa Predeteanu, F. Berghea, M. Abobului, Violeta Vlad, Andra Balanescu, Daniela Opris-Belinski, Violeta Bojinca, C.L.Constantinescu, Andreea Borangiu, Laura Groseanu, Ioana Saulescu, Maria-Magdalena Negru, Sanziana Daia, Diana Mazilu, Ruxandra Ionescu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Romanian Journal of Medical Practice, Vol 27, Iss 3, Pp 127-132 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1843-0791 2069-6108 |
| DOI: | 10.37897/RJR.2018.3.5 |
| Popis: | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which deposit within tissues and fix complement leading to systemic inflammation (1). Is a heterogeneous disease with a continuum of disease activity. Some patients can have predominant skin and joint involvement, whereas others can present with organ-threatening diseases such as nephritis, cardiac involvement or even neurologic manifestations. Relatives of patients with SLE appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable (2,3). |
| Databáze: | Directory of Open Access Journals |
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