Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Autor: J. L. Barton, L. Pincus, J. Yazdany, N. Richman, T. H. McCalmont, L. Gensler, M. Dall'Era, K. H. Fye
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Case Reports in Rheumatology, Vol 2011 (2011)
Druh dokumentu: article
ISSN: 2090-6889
2090-6897
DOI: 10.1155/2011/242681
Popis: Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.
Databáze: Directory of Open Access Journals
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