Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis

Autor: Takeshi Suzuki, Yoshitaka Sato, Yusuke Okuno, Fumi Goshima, Tadahisa Mikami, Miki Umeda, Takayuki Murata, Takahiro Watanabe, Koichi Watashi, Takaji Wakita, Hiroshi Kitagawa, Hiroshi Kimura
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03581-9
Popis: A genome-wide CRISPR screen for HSV-1 host factors using near-haploid HAP1 cells revealed PAPSS1 as an essential factor for heparan sulfate biosynthesis and HSV-1 infection, and identified several other host factors also involved in both processes.
Databáze: Directory of Open Access Journals
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