| Autor: |
S. Maleškić Kapo, M. Rakanović-Todić, L. Burnazović-Ristić, J. Kusturica, A. Kulo Ćesić, E. Ademović, S. Loga-Zec, A. Sarač-Hadžihalilović, I. Aganović-Mušinović |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of King Saud University: Science, Vol 35, Iss 1, Pp 102394- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1018-3647 |
| DOI: |
10.1016/j.jksus.2022.102394 |
| Popis: |
Objectives: Topical forms of Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain, fever and inflammation ensure reduced occurrence of systemic adverse effects that are common with oral application. Compared to the systemic therapy, topical applications of NSAIDs require lower doses to achieve pain relief, and thus pose lower risk of major drug interactions. We aimed to evaluate analgesic and anti-inflammatory effects of diclofenac and ketoprofen patch in the rat model of acute inflammation. Methods: Wistar male rats, body weight 220–290 g were randomized into five groups with six rats. Two groups were treated with diclofenac patch at different doses, two with ketoprofen patch at different doses, while a placebo patch was administered to the control group. After patches removal and initial measurements of pain, gait, body temperature, paw temperature, color and paw volume, the models of acute inflammation were applied: yeast-induced hyperalgesia and carrageenan-induced edema. Measurements were repeated one, three and five hours after inflammation induction. Results: Acute inflammations induced by both used models did not affect the whole-body temperature. However, there were significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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